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KMID : 1004820070080010005
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Journal of Biomedical Research
2007 Volume.8 No. 1 p.5 ~ p.14
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Use of P/Q-type Calcium Channel Mutant Rodents in Neurological
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Nahm Sang-Soep
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Abstract
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Recent progress in molecular techniques has identified many human channelopathies related to ion channel mutations. In particular, calcium channelopathies in humans cause diverse range of symptoms and syndromes including ataxia, migraine, neuromuscular disorders and possibly epilepsy. As calcium is one of the most important ions that regulate cellular function, calcium channel mutant mice and rats are getting more attention as models to study human neurological disorders. The calcium channel mutants exhibit ataxia, absence seizures and various degree of cerebellar neuronal loss, which mirrors symptoms caused by human calcium channel mutations. Thus P/Q-type calcium channel mutants provide useful animal models to study neurological disorders associated with human calcium channelopathies.
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KEYWORD
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tottering, leaner, Nagoya rolling, wobbly, groggy, P/Q-type calcium channel knockout
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